![]() In summary, our results characterize the development of class IV neurons and provide a framework to understand how the large-scale morphology of the class IV neuron dendritic tree emerges from the local stochastic growth of its branches. Within the limitations of the model, this more fine-grained approach predicts morphometrics that agree with the measured values. Second, we construct an agent-based model of morphogenesis that implements the stochastic rules of microscopic tip growth and branching whose combined effects lead to the development of the dendritic tree. This coarse-grained approach predicts that the dendritic tree grows by the propagation of a density wave whose tail stabilizes to a steady-state. Some PNS neurons have a single dendrite (external sensory. First, we use the mean-field approximation to formulate dendritic tree growth as a system of reaction-diffusion equations with two kinds of species, dendrites and tips. The embryonic and larval PNS consists of a well-defined array of sensory neurons in each hemisegment. Here we show that dynamically growing somatosensory neurons in the Drosophila peripheral nervous system exhibit organ sparing at the level of arbor growth: Under nutrient stress, sensory dendrites preferentially grow as compared to neighboring non-neural tissues, resulting in dendrite overgrowth. Driven by the results of our analysis, we propose two types of model of morphogenesis. We find that the tip growth dynamics can be described by a Markov process that transitions between three velocity states: growing, paused and shrinking. Figure 1.Developmental dendrite remodeling in a variety of neurons. We begin by analyzing the tip dynamics and branching process of class IV dendritic trees. In this study, we aim to bridge this gap by formulating multi-scale models of neuronal dendritic morphogenesis. However, it is yet unknown how the microscopic dendritic growth processes produce the macroscopic morphology of the class IV neurons. The fully-developed dendritic tree results from a multitude of stochastic processes including dendritic tip growth, branching and self-avoidance. The class IV neurons of the Drosophila melanogaster larva are two-dimensional sensory neurons that develop a complex dendritic arbor sensitive to mechanical stimuli. Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, DeRisi JL, Jan. The establishment of the neuron's morphology is essential to its function.
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